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In protein modification, glyoxal and MG act as potent glycating agents, generating lysine-derived adducts (CML and CEL residues), bis(lysyl) crosslinks (GOLD and MOLD), and AGEs (G-H1 and MG-H1)

Integrating these approaches with conventional treatments such as phototherapy or topical corticosteroids may offer a comprehensive therapeutic strategy to manage vitiligo by protecting melanocytes from oxidative stress and ferroptosis (136)

This Wnt-axis activity helps explain several otherwise disconnected observations why GHK-Cu promotes hair regrowth, why it extends fibroblast proliferative lifespan, and why it appears to reset certain senescence markers in aged skin cells