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It has also been observed that iron overload is one of the primary manifestations of thalassemia, which to a large extent leads to the occurrence of terminal organ joint complications in thalassemia patients

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One plausible explanation for these results is that the gpoA mutant is unable to effectively counteract the elevated ROS concentrations encountered within the intracellular environment of host cells, despite the partial compensatory activity of the TpxD and AhpD peroxidases (Fig

[7] [8] References [edit] 1 2 3 GRCh38: Ensembl release 89: ENSG00000243955 Ensembl, May 2017 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057933 Ensembl, May 2017 "Human PubMed Reference:"