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[DOI] [PubMed] [Google Scholar] 67.Vidal F, Lorenzo A, Auguet T et al

For example, mutations in the IVD gene encoding the enzyme for leucine degradation cause isovaleric acidemia, in which the intermediate isovaleric acid accumulates and damages the brain and nervous system (Vockley and Ensenauer, 2006)

Archives of neurology , 50 (7), 739742

When the finely-tuned trafficking of macromolecules is dysregulated in genetically susceptible individuals, both intestinal and extraintestinal autoimmune disorders can occur.[105] There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases

p-hydroxybenzoic acid and mevalonic acid as precursors of the plant naphthoquinone alkannin