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Starting metformin alongside intensive lifestyle modifications is advisable [] , and it is usually continued throughout treatment unless contraindicated

The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes

Recent studies showed that administration of glutathione (in an ester form) to guinea pigs fed an ascorbatedeficient diet significantly delays the onset of scurvy, a disease in which oxidative stress leads to inactivation of certain enzymes that catalyze hydroxylation reactions

Notably, Saikosaponin A, Tanshinone IIA, Schisandrol B, and Ganoderic acid A, along with their selected UA-related transporters, exhibit strong binding energies, as shown in Figures 9AD