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Pharmacologic and genetic interventions that suppressed MSCs proliferation successfully preserved hair pigmentation under stress, confirming the link between norepinephrine release and hair graying (Figure 3)

Li Y, Chen H, Yang Q, Wan L, Zhao J, Wu Y, et al

Glutathione Deficiency in Patients with Mitochondrial Disease: Implications for Pathogenesis and Treatment

185 , G43G67 (2021)

Strikingly, untargeted metabolomics also revealed significantly elevated hepatic levels of seven standard amino acids in Gpr146 / mice, namely histidine, cysteine, lysine, valine, leucine, isoleucine, and phenylalanine (Supplementary Fig