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Acknowledgements 20

Dysregulation of these pathways is accompanied by an enhancement of obviously changed G protein-coupled receptor (GPCR) signaling pathways (Huot et al., 2011

Bioidentical progesterone metabolizes into allopregnanolone, which activates GABA receptors in the brain

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Furthermore, heat stress can induce reorganization of the intestinal cytoskeleton and downregulate the expression of tight junction proteins between intestinal cells, further exacerbating intestinal barrier dysfunction in human intestinal epithelial Caco-2 cells [18]