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Integrated analysis of microbiome and transcriptome reveals the mechanisms underlying the chlorogenic acid-mediated attenuation of oxidative stress and systemic inflammatory responses via gut-liver axis in post-peaking laying hens

In parallel, molecularly engineered carrierfree prodrug nanoassemblies represent an alternative strategy to improve stability and achieve controlled activation without relying on conventional liposomal or polymeric carriers

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doi:10.1073/pnas.93.25.14960

They obtained fasting plasma ascorbic acid levels and subsequently provided a 1,000 mg loading dose of ascorbic acid