biologic and pharmacologic regulation of mammalian glutathione synthesis The Emerging Roles γ-Glutamyl Peptides Produced by γ-Glutamyltransferase the System Glutathione Metabolism - an overview

10.1007/s00401-010-0788-5 132 LermyteF.EverettJ.LamY

Epub 2005 Dec 13

Studies have shown that erastin and sulfasalazine can interfere with cystine absorption by inhibiting system Xc- activity, causing a reduction in GSH synthesis and a decrease in GPX4 activity, thereby inducing lipid peroxidation and cell death [24]

Hydration matters more than people realize

Nucleic acids, particularly abundant in meat due to the multinucleated nature of muscle tissue, can also serve as a fuel sourcealbeit minimalupon degradation to D-ribose, a metabolite that is taken up avidly by peripheral tissues 7,8 and processed by a cytosolic ribokinase 9