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5 mg Vials (Twice Weekly) 8 weeks 3 vials (~10.2 mg total) 12 weeks 4 vials (~18.2 mg total) 16 weeks 6 vials (~26.2 mg total) 2 mg Vials (Once Weekly) 8 weeks: 8 vials (1 vial/week) 12 weeks: 12 vials (1 vial/week) Insulin Syringes (U-100) Twice Weekly: 2 syringes/week 8 weeks: 16 syringes , 12 weeks: 24 syringes , 16 weeks: 32 syringes Once Weekly: 1 syringe/week 8 weeks: 8 syringes , 12 weeks: 12 syringes Bacteriostatic Water (10 mL bottles) Use 1.0 mL per 2 mg vial or 2.0 mL per 5 mg vial for reconstitution

No bacteriostatic water contains 0.9% benzyl alcohol as a preservative that inhibits bacterial growth in multi-dose vials, while sterile water for injection contains no preservatives and must be discarded after single use

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Conclusions MSPs need special consideration for genotoxicity assessment due to the probable inapplicability of the Ames test