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In neuropathic pain, TRPM2 deletion reduced microglial production of chemokine CXCL2 and NO, as well as inflammatory markers including Iba-1 and components of the NLRP3 inflammasome complex, indicating that TRPM2 regulates not only microglial numbers but also their morphology and molecular profile

Crucially, most neurodegenerative phenotypesparticularly late-onset formsare polygenic and multifactorial, frequently arising from variants of incomplete penetrance and variable expressivity

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A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers