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3.2.4 HO-1 Heme oxygenase-1 (HO-1) is an enzyme involved in the breakdown of heme molecules, converting them into biliverdin, carbon monoxide (CO), and ferrous iron (Fe 2+ ) (Figure 2)

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As a consequence, PUFAs with deuterium at the bis-allylic carbons are unable to undergo peroxidation