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10.3389/fphar.2020.00859 122 XiaoW.ShiH.TianY.ChenF.XieY.HanX.et al (2025)

This activation ramps up the metabolism (1) (usually making patients lose weight), increases heart rate (causing palpitations), increased adrenaline release (making you feel jittery and anxious), and leads to diarrhea (through activation of the GI tract)

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Mechanical activation of hypoxia-inducible factor 1 drives endothelial dysfunction at atheroprone sites

(Giuliante et al., 2015) reported pronounced elevation of NNMT protein expression, gene expression, and enzyme activity in the adipose tissue of rats afflicted with MetS