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Morris, VK, Overman, MJ, Lam, MC, Parseghian, C, Johnson, B, Dasari, NV, Raghav, KS, Kee, BK, Huey, RW, Wolff, RA, Shen, JY, Li, J, Zorrilla, I, Tzeng, CD, Tran Cao, HS, Chun, YS, Newhook, TE, Vauthey, JN, Duose, D, Luthra, R, Haymaker, CL, Kopetz, S

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Replacement of CoA with carnitine generates free CoA in the mitochondria

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To explore why cytosolic NADPH level increased during EC senescence, we examined the protein levels of NADPH-generating enzymes in primary cultured HAECs, including G6PD and PGD in pentose phosphate pathway, IDH1 in citric acid cycle, ME1 in malate-aspartate shuttle, MTHFD1 in folate metabolism, and NAD kinase (NADK) (Supplementary Fig