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doi: 10.3389/fmed.2022.841112

Neuroinflammation also emerges as a critical determinant: elevated cytokines such as TNF- , IL-1, and IL-6 destabilize synaptic homeostasis, impair inhibitory neurotransmission within descending pain pathways, and exacerbate central sensitization, ultimately limiting the therapeutic impact of tDCS (9698)

However, only motifs 2 and 3 had a relation with the peroxidase (PF00141) protein family, and in this case were present in most of the sequences

These mitochondrial interactions offer glimpses of the viral effect on glycolytic and oxidative phosphorylation pathways and the potential side effects

Microscopically, airway inflammation, edema, and hemorrhage were shown as well as pericentral necrosis