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All TLRs (bar TLR3) induce the expression of inflammatory cytokines through a conserved signalling pathway, starting with the translocation of the adapter molecule myeloid differentiation factor 88 (MyD88) which ultimately leads to the early activation of nuclear factor kappa B (NFB) (Figure 3) (Yamamoto et al., 2003

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Additionally, RNF8 and HUWE1 may also catalyze K63-linked polyubiquitination of histone H1 to recruit RNF168 to DSBs (Thorslund et al

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