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(A) Noble Metal Nanozyme: Schematic illustration of the RuNZs multienzymatic activities, highlighting NO adsorption at Ru 0 sites and ROS scavenging mediated by Ru 4+ centers

W222 is rotated and pushed aside to accommodate the phenyl group of C4-10 , which is inserted deeply into the protein surrounded by W222, F225, L226, I131, M187, R183 and V127

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To characterize the pharmacokinetics of repeated high oral doses of NAC and their effect on brain and blood oxidative stress measures, we conducted an open-label, prospective 4-week study of oral NAC in individuals with PD (n=5) and healthy controls (n=3)