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Among the most clinically advanced biomimetic delivery systems, allogeneic human adipose mesenchymal stromal cell-derived exosomes (MSC-EVs) have entered Phase I/II clinical trials in patients with mild to moderate AD, where repeated intranasal administration was shown to be safe and well tolerated, with preliminary evidence of cognitive stabilization and reduced hippocampal atrophy

As supplements are metabolized by the digestive system, fewer vitamins, nutrients, and medications enter the bloodstream, increasing the effectiveness of treatment

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The animal model uses the CCl4 targeting different mechanisms to induce oxidative stress

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