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Several mechanisms explain how anti-PD-1/PD-L1 therapy may expand and enhance Treg function

Lin P, Cao M, Xia F, Liao H, Sun H, Wang Q, et al

Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4