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SLC22A5 mutations impair OCTN2 function, causing primary carnitine deficiency (PCD) ( Beyond genetic determinants, OCTN2 expression and function undergo significant physiological and pharmacological regulation

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The mRNA expression of acetyl-CoA acyltransferase ( acca ) ( P = 0101) and peroxisomal biogenesis factor 11 gamma ( pex11 ) ( P = 0071) in the HF/H-LC group was higher than that in the HF group by at least 80 %, but the difference was not significant

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Classification criteria were the number of patients showing (1) improvement in pneumonia lesions, (2) worsening of pneumonia lesions, (3) stable pneumonia lesions, and (4) resolution of pneumonia lesions