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Gene-expression profiling studies have reported that GHK-Cu alters the transcription of a broad set of genes linked to tissue remodeling, antioxidant defense, and inflammatory signaling

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The pharmacokinetic evaluable analysis set was defined as all randomized participants who received BUP-XR injection and provided an adequate number of post randomization pharmacokinetic samples to derive the primary endpoints

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Oxidative stress plays a role in downregulation of the transcription factor MAFA, which influences insulin secretion by pancreatic beta cells [82]

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