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Modifying the carrier surface with targeting molecules such as aptamers or functional peptides can improve local drug retention and specificity in diseased cartilage or pathological synovial cells, while reducing potential adverse effects from systemic exposure

Moreover, copper ions can stimulate the activation and proliferation of adaptive immune cells (187), reverse topical immune suppression (188), and play an essential role in the immunotherapy of tumors (189)

DPPH, 2,2diphenyl1picrylhydrazyl assay

Zhao J, Wang J, Zhao K, Zhang Y, Hu W (2024a) Protopanaxadiols eliminate behavioral impairments and mitochondrial dysfunction in Parkinsons disease mice model

Although it is unclear why symptoms persist, there is a belief that it results from residual damage of tissues or infection from lingering bacteria