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What are the risks, limitations, and unknowns

Cited 4/30/19 Benowitz NL (2021): Antihypertensive agents (Chapter 11)

In the early 2000s, its use declined as alternative diagnostic strategies and recombinant hormone assays became more widely available

Potential side effects can include: Increased appetite Mild water retention Temporary swelling in the hands or feet Fatigue or lethargy Numbness or tingling sensations Joint stiffness Increased fasting blood glucose in susceptible individuals Most of these are dose-dependent and often improve with dosage adjustments