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SKU: 97256346715
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Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders

Senescent macrophages release inflammatory cytokines and RNA-loaded extracellular vesicles to circumvent fibroblast senescence

Specifically, free ferric iron is shuttled into cells bound by transferrin (TF), and reduced to ferrous iron via catalyzing by endosomal six-transmembrane epithelial antigen of prostate 3 (STEAP3), subsequently ferrous iron is released into the cytoplasm through divalent metal transporter 1 (DMT1) to expand the labile iron pool (LIP) (Xu et al., 2024)

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