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So, the route of administration matters

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The Journal of international medical research

Patients were randomized (n=456) to receive pemetrexed 500 mg/m2 intravenously over 10 minutes followed 30 minutes later by cisplatin 75 mg/m2 intravenously over two hours on Day 1 of each 21-day cycle or to receive cisplatin 75 mg/m2 intravenously over 2 hours on Day 1 of each 21-day cycle

HSL inhibition in M2 macrophages caused a significant downregulation of M2-associated genes, including the master regulator PPAR and the functional markers CD206 , CD36 , and CD200R1 (Supplementary Fig