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Mechanistically, A5 suppresses HMGB1/NF-B signaling, activates the Nrf2/HO-1 pathway, promotes anti-inflammatory M2 microglial polarization, and limits peripheral immune infiltration, collectively reducing ferroptosis and secondary injury ( 3.3.2 Neurodegenerative diseases 3.3.2.1 Alzheimers disease (AD) and Parkinsons disease (PD) Ferroptosis is increasingly implicated in the progression of Alzheimers disease (AD) and Parkinsons disease (PD) ( TFRC and ALOXE3 to enhance iron accumulation and lipid peroxidation (Wu et al., 2023)

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Acta 1862, 1137 (2016), Application(s): Western blot, Abstract Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells: Y

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In another field, in vitro studies have demonstrated that treatment with plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) increased HMOX1 production