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1 H NMR (400 MHz, D 2 O, ppm): = 4.624.53 (m, 1H), 3.74 (s, 2H), 3.70 (t, J = 6.2 Hz, 1H), 2.802.69 (m, 1H), 2.592.50 (m, 1H), 2.482.39 (m, 2H), 2.142.03 (m, 2H)

We sought to test the hypothesis that inhibition of the CD38 ecto-enzymatic activity using a heavy-chain monoclonal antibody Ab68 will, via augmenting organismal NAD + , prevent fibrosis in a mouse model of SSc characterized by NAD + depletion

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Iron and heme in tumor-associated immune cells There is increasing evidence that iron metabolism differentially affects the composition and polarization of immune subsets, ultimately contributing to distinct immune cell function, immunosuppression and tumor progression