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10.1016/j.ceb.2020.01.001 Curr

Each drug hits certain pathways and there are clues there: Nicotine and stimulants - acetylcholine and glutamate (so maybe reduced glutamate, to begin with) Benzos - GABA (so maybe too much glutamate) Alcohol - GABA and serotonin (plus just about everything) a depressant so too much glutamate