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Reactive astrocytes, in response to oxidative stress, alter the expression of key enzymes such as nitric oxide synthase (NOS), NADPH oxidase (NOX) enzymes and fatty acid amide hydrolase, which, in turn, enhance the production of oxidative agents 93

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Why withdrawal develops When benzodiazepines are reduced or removed, these neuroadaptations create a temporary imbalance where inhibitory tone is relatively low and excitatory activity is relatively high

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You can find genetic testing with various companies such as 23andme.com Its estimated that those with one mutation (heterozygous) decrease their ability to methylate by 30% and those with two mutations (homozygous) decrease their ability to methylate by 70%, making it virtually impossible to get adequate B12 from diet alone (19)