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However, doxorubicin induces mitochondrial dysfunction, this might be due to increased nitric oxide production, accumulation of iron in mitochondria, and ROS production due to futile redox cycling (42)

This effect is supported by activation of the Rap1 signaling pathway, which strengthens intercellular junctions, enhances NO production, and reduces inflammation

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IHC analyses were therefore performed in order to examine the relative expression levels of TH in the hippocampal tissues of the mice

Lactate and lactate dehydrogenase in cistern as biomarkers of early brain injury and delayed cerebral ischemia of subarachnoid hemorrhage