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Patients assigned to tirzepatide showed a 20.9% BW loss after 36 weeks with an additional 5.5% reduction after 52 weeks, while those who switched to placebo experienced a 14% weight regain, confirming the findings from STEP 4 supporting the chronicity of obesity and the need for continuous treatment

The C-terminus of TRPM2, 6, and 7 have enzymatic domains (Guo et al., 2017

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These findings illuminate the functional consequences of disconnecting histone modification crosstalk for a key epigenetic enzyme