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B12 Deficiency in Thalassemia Patients: Prevalence and Causes B12 deficiency in thalassemia patients Thalassemia and B12 deficiency have a complex relationship

"Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation"

Serious adverse events are rare but include pituitary axis suppression with long-term high-dose use and worsening insulin resistance in patients with pre-existing glucose issues

Vitamin B12 deficiency after total gastrectomy is often thought of as macrocytic anemia, but neurological symptoms can also occur, although they are rare [10,11]

The dose that reaches fibroblasts is still low compared to what systemic delivery achieves