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A degenerated IVD can be analogous to a deflated tire, characterized by diminished disc height and compromised axial compressibility, along with augmented and variably unstable radial bulges (Vergroesen et al., 2014

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(2017) further supported rutins antidepressant potential by observing a dose-dependent decrease in immobility time during the tail suspension test (TST) in mice treated with rutin (Yushau et al., 2017) (Figure 3)

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