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Classification and chemical structures of ADC linkers [2] As of December 2025, 21 ADCs have received global approval (Table 1)

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Lenalidomide (Len) in combination with Rituximab demonstrated early evidence of efficacy in a phase I/II study in relapsed/refractory mantle cell lymphoma (MCL)

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Furthermore, the long non-coding (lnc)RNA KCTD21-AS1, modified by METTL14-mediated N6-methyladenosine methylation, acts as a competing endogenous RNA for miR-519d-5p to regulate CD47 and TIPRL expression, thereby modulating macrophage phagocytosis and autophagy in LC cells (24)

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Based on the spectrum of their biological activity, natural products are considered attractive

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