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Piperine acts as a potent metabolic inhibitor that significantly alters how the body processes curcumin

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HPF1 interacts with several critical residues (Trp1014, Ser1012, Leu985, His826, and Leu1013) in the catalytic domain of PARP1 through its Lys307, Asp283, Cys285, Phe268, and Phe280 residues in the C-terminal domain

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Faber PW, Kuiper GG, van Rooij HC, van der Korput JA, Brinkmann AO, Trapman J

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