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While NRF2 activates NADPH production through the upregulation of the pentose phosphate pathway, malic enzyme, and isocitrate dehydrogenase, NRF2 also supports cellular NADPH levels by suppressing NADPH-consuming processes

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10.3389/fnbeh.2023.1176382 [DOI] [PMC free article] [PubMed] [Google Scholar] Purpura M, Jger R, Falk M (2021) An assessment of mutagenicity, genotoxicity, acute-, subacute and subchronic oral toxicity of paraxanthine (1,7-dimethylxanthine)

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Peptide approaches for perimenopause may benefit from combining pineal peptides with compounds that address the broader hormonal picture