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While this mechanism explains the negative impact of ablative radiation doses on abscopal responses in a murine mammary carcinoma model (Dewan et al., 2009), the observation is not consistently held up in non-abscopal readouts of tumour immunity, suggesting that other factors may be involved in this regulation (Burnette et al., 2011

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Am J Respir Crit Care Med 176: 270276 200611-1722OC [pii];10.1164/rccm.200611-1722OC [doi]

Cytokine storm induced by SARS-CoV-2 infection: the spectrum of its neurological manifestations

Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases