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While HO exerts the most significant negative impact on 20-year overall survival and CV health in CO CP children treated during the transition period [98], the heightened CV risk observed in these patients is multifactorial, also resulting from neuropsychological impairment, eating disorders, hormonal deficiencies (e.g., hypothyroidism and GHD), and associated lipid and glucose disorders [43, 164]

Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses

Overall cellular energy production and mitochondrial health