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This conclusion was challenged when pretreatment with the neutropenia-inducing antibody Gr1 resulted in reduced liver injury [116]

Plausible mechanisms for STAT3 -enhanced resistance include upregulation of the anti-apoptotic proteins BCL2 and BIRC5/Survivin, the oncogene MYC , EMT genes [125], and activation of ATF6, resulting in ER stress response and autophagy [126]

Tolerance to drought stress under ABA can be associated with negative effects on tree productivity, causing senescence and leaf fall 15

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Results Treatment protocol This cohort of eight female and one male pwCF, median age 32 years (range 2246 years), were the first nine patients treated with compassionate phage therapy because of MDR (seven patients) or PDR (two patients) PsA that did not respond to standard cystic fibrosis (CF) therapies (Table 1)