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Doses vary from 1,000 to 4,500 mg per day

the reduction in Health Assessment Questionnaire Disability Index (HAQ-DI) was 0.50 at 24 weeks for the combined certolizumab pegol groups compared with 0.19 for placebo

The RCT is the most scientifically rigorous method of hypothesis testing available, and is regarded as the gold standard trial for evaluating the effectiveness of interventions