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In a study on breast cancer cells treated with CAPE and several effective CAPE derivatives, these compounds showed activation of caspase-3 and caspase-7 apoptotic activity and similar potency of NF-B modulation activity ( 3.3 Xanthohumol and derivatives XN is a prenylated flavonoid derived from Humulus lupulus L, a typical beer hop plant, and a member of the Cannabiaceae family utilized in the brewing process for its aromatic properties (Magalhes et al., 2009)

Since the brain cannot synthesize folate, it relies on transport across the BBB via the folate receptor alpha (FR)

Orsini M, Oliveira AB, Nascimento OJ, Reis CHM, Leite MAA, de Souza JA, Pupe C, de Souza OG, Bastos VH, de Freitas MR (2015) Amyotrophic lateral sclerosis: new perpectives and update

Norrby-Teglund A Article: PLOS ONE