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EMT is characterized by the downregulation of cell-cell adhesion molecules, including E-cadherin, and the upregulation of mesenchymal markers, such as SMA, fibroblast-specific protein 1 (FSP1), fibronectin, collagen, and vimentin (70)

Importantly, routine thyroid function testing is not required by the label, though Zepbound is contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2

FIGURE 9 Discussion Nrf2 is a key member of cap-n-collar basic leucine zipper transcription factor family, and is also a key regulator of mammalian genes involved in cell protection and detoxification by preventing oxidative stress ( As the first step of metabolism, the liver is often exposed to high concentrations of exogenous and endogenous metabolites, especially vulnerable to oxidative damage caused by intermediate active substances

These include: 1) oxidative stress and mitochondrial damage, where viral factors induce ROS accumulation and mitochondrial dysfunction, leading to cellular damage, impaired autophagy/mitophagy, and primed inflammatory pathways

However, as we age or experience high levels of stress, our production of catalase and glutathione begins to dip