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Evid Based Complement Alternat Med 2013:705121 Ugbaja RN et al (2021) Lycopene abrogates obesity-provoked hyperactivity of neurosignalling enzymes, oxidative stress and hypothalamic inflammation in female Wistar rats

In addition, all participants underwent a screening that included medical history, physical examination, standard blood tests, and a 2-h OGTTwith exclusion of individuals with diabetes, liver disease other than metabolic dysfunctionassociated steatotic liver disease, excessive alcohol intake, physical activity (PA), or use of medications known to affect metabolic outcomes, including hypoglycemic agents, systemic corticosteroids, and lipid-lowering therapies

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peripheral vasospasm is believed to be present, causing increased peripheral resistance

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