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Moreover, a systematic analysis of liver tissues from patients with primary hyperoxaluria revealed high rates of chronic liver disease, hepatic inflammation and fibrosis in patients with AGXT dysfunction 21

28 Dos Santos SouzaC.GrangeiroM

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This is accomplished through the upregulation of key SMAD proteins SMAD2, SMAD3, and SMAD5, serving as intracellular effectors of the TGF- signaling pathway, which is crucial for follicular development, oogenesis, and GCs function