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J Biol Chem 274 : 28662871 Gladyshev VN, Jeang KT, Stadtman TC 1996 Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

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Similarly, trials in which a combination of several antioxidants was administered (vitamins C, E, selegiline, selenium, and L-methionine) also failed to show any improvement in ALS patients (Orrell et al., 2008)