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Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11

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Levels of pY were normalized to total IGF1R levels and shown as intensities relative to that of IGF1R WT in 50 nM IGF1 treated cells

Lentivirus production and cell culture Lentivirus expressing short hairpin RNA (shRNA) of Ssu72 was generated according to the protocol using packaging plasmids psPAX2 and pMD2.G [75]