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Clinical research provides guidance on safe, effective treatment durations

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Extravasation: A severe form of infiltration where a vesicant drug leaks into tissue, causing blistering, necrosis, and tissue damage

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The dosage is highly variable and determined solely by the treating physician based on diagnosis (e.g., severity of deficiency, presence of neuropathy)

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More recently, the A946T variant alone was confirmed to lead to increased basal type I IFN activity in reporter cell lines due to increased MDA5 ATPase activity, which may enhance filament formation on dsRNA and downstream signaling (115)

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