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Furthermore, since ESM1 maintains tumor angiogenesis through regulation of the EGFR signaling pathway, and rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/ERK and PI3K/AKT are the main signaling pathways downstream of EGFR (55,61), ESM1 can also regulate these pathways

After the combined use of a low concentration of APBMV (20 mg/L, cell inhibition rate is only 15.5%) and chemotherapeutic drugs such as mitomycin (MMC), DDP, fluorouracil (5-FU), and VP-16, the sensitivity of colorectal cancer LoVo cells to chemotherapeutic drugs increased and the cell inhibition rate even Increased to about 2 times that of those drugs used alone

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