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Established cellular importance does not prove that every external formulation is beneficial

MA13.07 TROPION-Lung02: initial results for datopotamab deruxtecan plus pembrolizumab and platinum chemotherapy in advanced NSCLC

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However, neurodegenerative disease mechanisms differ substantially between animal models and human diseases, and premature clinical use based solely on animal data could expose patients to unknown risks without established benefits

However, even when sufficient tumor-specific T-cell clones are present, their functional state and differentiation fate within the immunosuppressive TME are equally critical, as an unsustainable immune response ultimately leads to treatment failure