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Diminished levels of monoamines, altered sensitivity of receptors, and dysregulated transport mechanisms such as SERT and NET play a significant role in the manifestation of depressive symptoms (24)

doi: 10.1002/pros.22943 247

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases