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Although MCHM has been linked to DNA damage, we did not observe an increase in mutations in treated cells

Pogarell O, Koch W, Karch S, Dehning S, Mller N, Tatsch K, et al

doi: 10.1172/JCI83657 73 LiuSPromesJAHarataMMishraAStephensSBTaylorEBet al

& De Cosmo, S

Adults under 60, rising to 20% in those over 60 Special flag / patients also taking metformin should monitor B12 closely due to documented depletion Key lab threshold / serum B12 0.4 mol/L) typically start with 1,000 mcg oral daily for 1 to 3 months, then reassess